Significance of Homologous Donor Blood to the Toxic Reaction in Dogs Undergoing Extracorporeal Hemodialysis

Application of hemodialysis to dogs has been complicated by mi acute reaction consisting of hypotension, brudycardia, and respiratory depression followed by instability and a mortality rate of about 30 per cent. This reaction appeal's to be a response to homologous blood used to fill the dialyzers. Sensitization ocelli's in survivors, and accentuated reactions with marked hemolysis are noted on subsequent challenge. Cross matching the donor and recipient bloods has not permitted an adequate determination of compatibility under the conditions of hemodialysis. Satisfactory hemodialysis may be accomplished in dogs by using autogenous blood or blood substitutes to fill the dialyzers.